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2 edition of Metabolism and pharmacokinetics of pentachlorophenol in fish found in the catalog.

Metabolism and pharmacokinetics of pentachlorophenol in fish

Guy Roland Stehly

Metabolism and pharmacokinetics of pentachlorophenol in fish

by Guy Roland Stehly

  • 299 Want to read
  • 31 Currently reading

Published .
Written in English

    Subjects:
  • Pentachlorophenol -- Physiological effect.,
  • Fishes.

  • Edition Notes

    Statementby Guy Roland Stehly.
    The Physical Object
    Paginationxvi, 1-31, 33-130 leaves, bound :
    Number of Pages130
    ID Numbers
    Open LibraryOL16617690M

      Pentachlorophenol (PCP) and its sodium salt were once widely used as a fungicide, bactericide, herbicide, mollusicide, algaecide and insecticide. Since , PCP use in the U.S. has been restricted, and it is used primarily as a preservative for wood to . 9. Guy R. Stehly, Metabolism and pharmacokinetics of pentachlorophenol in fish, 1 o. Atiqur Rahman, Drug distribution and biliary elimination, Abdur Rashid, Biliary excretion of xenobiotics, Irwin R. Schultz, Body size effects and species differences in the pharmacokinetics oftrifluralin in fish, Todd M. Ott

    Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the s, it is marketed under many trade names. [3] It can be found as pure PCP, or as the sodium salt of PCP, the latter which dissolves easily in al formula: C₆HCl₅O. The main processes involved in pharmacokinetics are absorption, distribution, and the two routes of drug elimination, metabolism and excretion. Together they are sometimes known by the acronym ‘ADME’. Distribution, metabolism and excretion are sometimes referred .

    The kinetics of accumulation of pentachlorophenol (PCP) at various pH values were investigated to explore how pH-dependent accumulation might influence PCP toxicity. Goldfish (Carassius auratus) were exposed to 5 mu g PCP/L in a static system buffered with mM bicine or N,N-bis(2-hydroxyethyl)aminoethane sulfonic acid (BES) at pH , , or Pentachlorophenol and its salts are used as biocides. Although they are used mainly for preservation and treatment of wood, their antimicrobial, antifungal, herbicidal, insecticidal and molluscicidal properties led to a widespread application of PCP formulations. Bevenue and Beckman reviewed the.


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Metabolism and pharmacokinetics of pentachlorophenol in fish by Guy Roland Stehly Download PDF EPUB FB2

PCP in gall bladder rapidly increased with exposure time and displayed a further increase even after fish had been transferred to running water, whereas a decrease was observed in all other organs.

PCP absorbed by goldfish was quickly excreted into surrounding water, mostly in a conjugated-form accompanied with a small amount of by: Metabolism of pentachlorophenol by fish. Interspecies variability in the metabolism of pentachlorophenol (PCP) was investigated by exposing rainbow trout, fathead minnows, sheepshead minnow, firemouth, and goldfish to water-borne super(14)C-PCP for 64 h.

The amounts of metabolites in bile and exposure water were species-dependent; all of the metabolites excreted into the water were sulphate. TOXICOLOGY AND APPLIED PHARMACOL () The Pharmacokinetics and Metabolism of Pentachlorophenol in Rats' W.

BRAUN, J. YOUNG, G. BLAU,2 AND P. GEHRING Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan Received November 3,; accepted February 1, The Pharmacokinetics and Metabolism Cited by: Pentachlorophenol (PCP) and pentachloroanisole (PCA) were rapidly taken up by rainbow trout when the concentrations of these compounds in water were μg/ml.

Following a 24 hr exposure of trout to 14 C-PCP the liver, blood, fat and muscle contaiand μg/g PCP, by: Excretion of pentachlorophenol C in the urine of rats and mice after oral and intraperitoneal administration (10 to 25 mg/kg) was studied. 41 to 43% of the excretion activity was found to be present as unchanged pentachlorophenol.

By means of gas chromatography-mass spectrometry, one metabolite was identified as tetrachlorohydroquinone, representing 5 and 24% of the excreted activity Cited by: Braun WH, Blau GE, Chenoweth MB () The metabolism/ pharmacokinetics of pentachlorophenol in man, and a comparison with the rat and monkey.

In: Deichmann WB (ed) Toxicology and Environmental Medicine. Elsevier North-Holland Biomedical Cited by: Pentachlorophenol (PCP) is widely used as an antifouling agent and wood preservative and has been shown to be toxic to fish at low concentrations (Norup, ; Holmberg et al., ). Recent work has confirmed the presence of low concentrations of O-methyl-PCP, pentachloroanisole (PCA), in tissues of lake trout from Lake Michigan (Veith, USEPA, Duluth, Minnesota; personal communication).Cited by: Sulfamonomethoxine has been efficacious in the treatment of various bacterial diseases of fish.

The present paper reviews recent studies on the metabolism and pharmacokinetics of sulfamonomethoxine in edible fish species such as yellowtail, rainbow trout, and by: 2. TOXICOLOGY AND APPLIED PHARMACOL () The Pharmacokinetic Profile of Pentachlorophenol in Monkeys W.

BRAUN AND M. SAUERHOFF Health and Environmental Research, Dow Chemical U.S.A., Midland, Michigan Received Ap ; accepted J The Pharmacokinetic Profile of Pentachlorophenol in by: Pentachlorophenol Hazard Summary Pentachlorophenol was once one of the most widely used biocides in the United States, but it is now a restricted use pesticide and is no longer available to the general public.

It was primarily used as a wood preservative. Pentachlorophenol is extremely toxic to humans from acute (short-term) ingestion and. Pharmacokinetics of pentachlorophenol in man.

Uhl S, Schmid P, Schlatter C. Pentachlorophenol (PCP) was given orally to three volunteers at single doses of, 9, and mg. Daily urinary excretion of PCP and PCP conjugated to glucuronic acid was monitored using gas chromatography with electron capture detection (GC/ECD).Cited by: @article{osti_, title = {Pentachlorophenol: Uptake/elimination kinetics and metabolism in an aquatic plant, Eichhornia crassipes}, author = {Roy, S.

and Haenninen, O.}, abstractNote = {Eichhornia crassipes [(Mart) Solms], an aquatic plant widely used for the treatment of wastewaters, was used to study uptake/elimination kinetics and metabolism of pentachlorophenol (PCP).

Braun WH, Young JD, Blau GE, Gehring PJ. The pharmacokinetics and metabolism of pentachlorophenol in rats. Toxicol Appl Pharmacol. Aug; 41 (2)– Uhl S, Schmid P, Schlatter C. Pharmacokinetics of pentachlorophenol in man.

Arch Toxicol. Feb; 58 (3)–Cited by: This study investigated the influence of titanium dioxide nanoparticles (n-TiO 2) on the bioavailability, metabolism, and toxicity of pentachlorophenol (PCP) in ish (Danio rerio) embryos or larvae (2-h post-fertilization) were exposed to PCP (0, 3, 10, and 30 μg/L) alone or in combination with n-TiO 2 ( mg/L) until 6 days by: Fungal Metabolism of Phenols, Chlorophenols, and Pentachlorophenol.

Factors Affecting Fungal Metabolism of Various Types of Phenols. Physiological Alterations of Fungi by Phenols. Taxonomic Relationship of Phenol‐Utilizing Yeasts and Fungi.

Mechanisms of Metabolism, Metabolic Pathways, and Metabolites. Degradation of Phenols by Fungal Enzymes. The biotransformation of pentachlorophenol (PCP), aniline and biphenyl in rainbow trout (Oncorhynchus mykiss) isolated liver cells was investigated to examine if fish hepatocytes represent a suitable alternative to the in vivo approach for studying the biotransformation of by: Pentachlorophenol and Dinitrophenolic Pesticides PENTACHLOROPHENOL Pentachlorophenol (PCP) is presently registered in the United States only as a restricted use pesticide for use as a “heavy duty” wood preservative.

It is registered only for use in pressure treatment of utility poles. Heavy duty wood preservatives are defined as. Eichhornia crassipes [(Mart) Solms], an aquatic plant widely used for the treatment of wastewaters, was used to study uptake/elimination kinetics and metabolism of pentachlorophenol (PCP).

PCP is a well‐known industrial by‐product and a major pollutant of the aquatic environment. The initial phase of PCP uptake by the plant was rapid and reached a nearly steady state between 24 and 48 h of. The metabolism of pentachlorophenol in animals and man was reviewed.

Tetrachlorophenols, 2,3,5,6-tetrachloro-1,4-benzoquinone, 2,3,4-trichlorophenol, 2,3,5-trichloro-1,4-hydroquinone, and their glucuronide conjugates were found in animals and man. Also identified were pentachlorophenylacetate, pentachloroanisole, and pentachlorophenylsulfate.

Pentachlorophenol is abbreviated as PCP. Product names include Dowicide EC-7, Penchlorol, Penta, Pentacon, Penwar, Priltox, Sinituho and Weedone. INTRODUCTION Pentachlorophenol (PCP) is a chlorinated hydrocarbon insecticide and fungicide. It is used primarily to protect timber from fungal rot and wood- boring insects.

The effects of oxygen availability on the degradation of pentachlorophenol (PCP) by coupled sludge granules and the granules' physicochemical characteristics were studied in batch experiments.

Results indicated that the quantity of available oxygen in serum bottles had a significant effect on the metabolism Cited by: 7.Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans.

As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to.This study investigated the influences of titanium dioxide nanoparticles (n-TiO 2) on the thyroid endocrine disruption and neurobehavioral defects induced by pentachlorophenol (PCP) in zebrafish (Danio rerio).Embryos (2 h post-fertilization) were exposed to PCP (0, 3, 10, and 30 μg/L) or in combination with n-TiO 2 ( mg/L) until 6 days post-fertilization.